As a landlord in South Carolina, it's crucial to screen potential tenants to protect your property and ensure a smooth rental relationship. Start by verifying their income, employment, and rental history. You can also conduct a background check and ask for references. Familiarize yourself with South Carolina's landlord-tenant laws, including the rules around security deposits and evictions. By following these steps, you'll be able to find reliable tenants who will respect your property and abide by state laws. Remember to always adhere to South Carolina landlord-tenant law to avoid any legal issues.