DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene. The gene DEPTOR can be found only in vertebrates. In human, DEPTOR gene locates at chromosome 8, 8q24.12 with protein size 409 aminoacids. DEPTOR is involved in mTOR signaling pathway as an endogenous regulator. A direct interaction between DEPTOR and mTOR has been shown. Overexpression of DEPTOR downregulates the activity of mTORC1 and mTORC2 in vitro. mTORC1 and mTORC2 can both inhibit DEPTOR through phosphorylation. Within the brain, DEPTOR is highly expressed in the hippocampus, the medio-basal hypothalamus and the circumventricular organs. Overexpression of DEPTOR in the medio-basal hypothalamus protects mice against high-fat diet-induced obesity by modulating Akt/PKB signaling. Here you can see a crystal structure of the human DEPTOR DEP domain tandem (PDB code: 7PED)
#molecularart ... #immolecular ... #deptor ... #regulator ... #mTOR ... #adipogenesis ... Rendered with @proteinimaging and finished with @corelphotopaint.
#molecularart ... #immolecular ... #deptor ... #regulator ... #mTOR ... #adipogenesis ... Rendered with @proteinimaging and finished with @corelphotopaint.
